Mohammad Sadidi; Mahmood Bakhtiyari; Amirhesam Alirezaei
Volume 21, Issue 2 , 2019, Pages 1-7
Abstract
Background: Some data suggest the protective effect of Portulaca oleracea against renal failure and its association with the preser-vation of the renal antioxidant status and the regulation of apoptosis.Objectives: The current study aimed to examine the renoprotective effects of treatment with Portulaca ...
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Background: Some data suggest the protective effect of Portulaca oleracea against renal failure and its association with the preser-vation of the renal antioxidant status and the regulation of apoptosis.Objectives: The current study aimed to examine the renoprotective effects of treatment with Portulaca oleracea (PO), a prominenthydrogen sulfide donor, in a 5/6 nephrectomy animal model.Methods: In this experimental study, 32 adult male Wistar rats, initially weighting 200 - 250 g, were housed under standard con-ditions since the beginning of April 2017 until the end of January 2018. The effect of PO extract on renal dysfunction induced bygentamicin was studied. The male rats were treated with two selected doses of PO (i.e., 200 and 600 mg/kg p.o.) and normal saline(5 mL/kg p.o.) for 28 consecutive days. Gentamicin (80 mg/kg/day intraperitoneally [i.p.]) was administered to two groups for sevendays, and they were considered as the PO200 and PO600 gentamicin groups, respectively, while the group administered normalsaline (5 mL/kg p.o.) for 35 consecutive days was considered as the control group. The rats were anesthetized on day 36. Then, theywere sacrificed under deep anesthesia, and plasma and tissue samples were obtained.Results: Treatment with PO decreased the renal histological damages and apoptosis induced by gentamicin and enhanced renalfunction parameters compared to the gentamicin group.Conclusions: The present findings provide strong evidence to support the traditional medicinal use of this herb by the tribal peoplein the treatment of renal impairment. Finally, these results support the therapeutic effect of PO in preventing the development ofrenal dysfunction.
